![]() As an endogenous molecule, agmatine has the capacity to inhibit stress- and LPS-induced increases in body temperature. Agmatine treatment inhibited LPS-induced production of nitrates dose dependently. To determine if the decrease in body temperature is associated with an anti-inflammatory effect of agmatine, the nitrite/nitrate levels in plasma was measured. Dhiwaakar Purusothaman Soundiah Regunathan Rajasekaran A Thesis Presented in Partial Fulfilment of the Requirements for the Degree Master of Science Approved April 2016 by the Graduate Supervisory Committee: Nathan G. Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor. When agmatine (80 mg/kg) was administered 30 min later than LPS (500 μg/kg) it also inhibited LPS-induced hyperthermia although the effect became significant only at later time points and lower maximal response compared to simultaneous administration. Song of the Spirit : The World of Sacred Music by Sudhamahi Regunathan (Ed.). Austin, Soundar Regunathan, Beata Karolewicz. While agmatine itself had no effect on body temperature, treatment with agmatine (20, 40, 80 mg/kg intraperitoneally) dose dependently inhibited stress- and LPS-induced hyperthermia. Rats were either restrained for 4 h or injected with LPS, both of these stressors caused an increase in body temperature. Agmatine is an amine formed by the decarboxylation of L-arginine by. The aim of the present study was to investigate the effect of agmatine on different models of stressors on body temperature. This response seems to share similar mechanisms with infectious fever. See the complete profile on LinkedIn and discover Regunathan’s connections and jobs at similar companies. Regunathan has 5 jobs listed on their profile. Physiological stress evokes a number of responses, including a rise in body temperature, which has been suggested to be the result of an elevation in the thermoregulatory set point. View Regunathan V’S profile on LinkedIn, the world’s largest professional community.
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